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Understanding the Contraindications of SSRIs with Psychedelic-Assisted Therapy (Part II)


Loosing my roots
Horse Skull and I

Acrylic Painting (c) Uriya Jurik


As an addiction recovery and psychedelic preparation and integration coach, I often encounter individuals seeking to explore the therapeutic potential of psychedelics such as psilocybin (found in magic mushrooms), mescaline (found in San Pedro cacti), or the DMT-containing brew ayahuasca. Many of these individuals are also on Selective Serotonin Reuptake Inhibitors (SSRIs) for depression or anxiety. It's crucial to understand the potential contraindications and interactions between SSRIs and psychedelic substances to ensure safety and efficacy in these exploratory therapeutic sessions.


SSRIs and Their Role

SSRIs are a class of drugs often prescribed for depression, anxiety disorders, and other mental health conditions. They work by increasing serotonin levels in the brain, which can help improve mood, sleep, and appetite. However, the interaction of SSRIs with psychedelic substances can be complex and potentially risky.


Potential Risks and Contraindications

  1. Serotonin Syndrome: One of the primary concerns with combining SSRIs and psychedelics is the risk of serotonin syndrome. This condition occurs when there is an excessive accumulation of serotonin in the brain, leading to symptoms ranging from mild (shivering, diarrhea) to severe (muscle rigidity, fever, seizures). Given that both SSRIs and certain psychedelics (e.g., psilocybin and ayahuasca) can increase serotonin levels, combining them may heighten this risk.

  2. Reduced Efficacy of Psychedelics: SSRIs may diminish the effects of psychedelics. SSRIs work by blocking the reuptake of serotonin, potentially leaving fewer receptors available for psychedelics to act upon. Anecdotally, some individuals report needing higher doses of psychedelics to achieve the desired therapeutic effect, which can increase the risk of adverse outcomes.

  3. Withdrawal and Discontinuation Syndrome: Abruptly stopping SSRIs to engage in psychedelic-assisted therapy can lead to withdrawal or discontinuation syndrome, characterized by flu-like symptoms, insomnia, nausea, imbalance, sensory disturbances, and hyperarousal. These symptoms can complicate the preparation for, experience of, and integration following a psychedelic session.

  4. Interaction with MAOIs: Ayahuasca contains monoamine oxidase inhibitors (MAOIs), which can dangerously interact with SSRIs. Combining MAOIs and SSRIs can lead to a dramatic increase in serotonin levels, significantly raising the risk of serotonin syndrome.

Safety Guidelines and Considerations

  • Medical Consultation: Anyone considering psychedelic-assisted therapy while on SSRIs should consult with a healthcare provider, ideally one knowledgeable about both SSRIs and psychedelics. This consultation should assess the risks and benefits specific to the individual's health status and psychological background.

  • Gradual Tapering: If it's decided to proceed with psychedelic therapy, a careful and medically supervised tapering off SSRIs may be necessary. This process should be gradual to minimize withdrawal symptoms and should be tailored to the individual's needs and response.

  • Integration Support: Preparation and integration are key components of a therapeutic psychedelic experience. Individuals should work closely with their coach or therapist to set intentions, prepare mentally and emotionally for the experience, and integrate their insights and learnings afterward.

  • Safety and Set and Setting: Ensuring a safe and supportive environment during the psychedelic experience is crucial. This includes having a trained facilitator or therapist present, choosing a comfortable and secure setting, and having support available for the integration process.

While psychedelic-assisted therapy offers promising avenues for mental health treatment, the combination of SSRIs and psychedelics requires careful consideration of potential risks and contraindications. With the right precautions, including thorough preparation, medical oversight, and integration support, individuals can minimize risks and enhance the therapeutic potential of their experiences. However, safety should always be the priority, and any approach should be personalized to the individual's unique psychological and medical context.


If you're ready to explore a more integrated approach to your healing journey, I invite you to reach out. Together, we'll create a tailored plan that honors your unique path, helping you move beyond temporary fixes to achieve deeper, more lasting healing.

Remember, healing is not a linear process, nor is it one-size-fits-all. It's a journey of discovery, understanding, and ultimately, transformation. Let's embark on this journey together, with openness, care, and a commitment to uncovering the deeper truths of your well-being.


Contact me today to begin your journey towards a more holistic and integrated approach to healing. Together, we'll explore the paths less travelled, uncovering the potential for profound healing and growth.

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